One-pot expeditious synthesis of pyrazoloindolones via base promoted electrocyclization, C-N coupling and intramolecular oxidative cyclization

Abstract

Pyrazoloindolones are synthesized from N-tosylhydrazones in one-pot multistep process which include base promoted (i) electrocyclization reaction of N-tosylhydrazones derived from α,β-unsaturated aldehydes, (ii) aromatic nucleophilic substitution and (iii) a domino cyclization-oxidation process under aerobic conditions.