Synthesis of Pyrido-Fused Imidazo[4,5-c]quinolines by I2-DMSO Promoted Oxidative Cross Coupling and Intramolecular Cyclization

Abstract

The synthesis of a series of novel quinoline fused imidazo[4,5-c]quinolines was accomplished by a simple, efficient, iodine–dimethyl­ sulfoxide (I2–DMSO) promoted sequential oxidative cross coupling­ followed by intramolecular cyclization of pyridoimidazole arylamines and carbonyl compounds in a one-pot reaction. Simple reaction conditions, no metal catalyst, no additives, no ligand, selective product formation and high yields are the advantages of this method.