Oncological outcomes of large gastrointestinal stromal tumors treated by laparoscopic resection.

Abstract

The resection of large gastric gastrointestinal stromal tumors (GISTs) by laparoscopic has been controversial. Extending from our prior study, the long-term oncological outcome of laparoscopic resection of large (5-8cm) gastric GISTs was reported. From 2002 to 2018, a consecutive 66 patients with gastric GISTs of 5-8cm were treated at National Taiwan University Hospital. Among them, 30 patients received open surgery, and 36 received laparoscopic surgery. The clinicopathological data, peri-operative and oncological outcomes were compared between groups. The clinical demographics including sex, age, BMI, tumor locations and ratio of wedge resection were similar between groups. The mean tumor size was 6.0 ± 0.83cm versus 6.3 ± 1.07cm (Open vs. Laparoscopic, p = 0.3). The operation time, blood loss, and post-operative complications, were also similar. The mean hospital stay was shorter in the laparoscopic group (8.8 ± 2.5days) than in the open group (12.0 ± 8.9days), though not significantly different. The median follow-up time was 108 ± 58months (97 ± 50 in laparoscopic group; 122 ± 64 in open group). All except three patients remain disease-free. One in the open group and two in the laparoscopic group had recurrence of tumor, and they were stable of disease under Imatinib treatment. Eight patients died in non-GIST causes during follow-up. The 5-year recurrence-free survival were 100% for the open and 94.2% for the laparoscopic group (p = 0.2). Our data showed that laparoscopic surgery for gastric GIST between 5 and 8cm was safe and oncologically feasible.