Abstract
Oncogene-induced NAD(+) depletion in tumorigenesis.
Highlights
A proto-oncogene has the potential to initiate cancer
Metabolic alterations are common fundamental characteristics of oncogenes and in this context, represent an essential hallmark of cancer, tackling primary metabolic defects can be an elegant approach to prevent and cure cancer. We summarize in this short editorial a recent example reported in Tummala et al of how targeting the metabolic defects prior to the high cellular proliferation and DNA damage can eradicate hepatocellular carcinoma (HCC) and prevent pancreatic cancer development [5]
Several pathways and molecular players were reported in HCC development, the lack of animal models that recapitulate the full spectrum of the human disease progression may impede the development of suitable therapies
Summary
A proto-oncogene (hereafter simplified as oncogene) has the potential to initiate cancer. We summarize in this short editorial a recent example reported in Tummala et al of how targeting the metabolic defects prior to the high cellular proliferation and DNA damage can eradicate hepatocellular carcinoma (HCC) and prevent pancreatic cancer development [5]. Development of tumors in the murine liver after ectopic URI expression in the whole body motivated us to study its role and function in liver disease.
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