Abstract
Oncofetal genes are primarily those genes that are expressed in fetal tissue but remain in a state of inactivation in adult. Assessing the various factors involved in reactivation of oncofetal gene, the predominant one that represent a distinct mechanism is bivalency. Evidence suggest that DNA methylation in context to bivalent domain of Histone 3 particularly at Lysine 4 and 27, serves as a major site for reactivation of silenced transcriptional activity along with protein complexes Tri-thorax (TrxG) and Poly-comb(PcG). The malignancy of proto- oncogene establishes a correlation with CpG rich DNA sequence that adds appropriate methylation providing rapid activation to express the silenced genes.
Highlights
Oncofetal genes are those genes which are produced or expressed during development of fetus but are found in adult tissue in very low amount
The malignancy of proto- oncogene establishes a correlation with CpG rich DNA sequence that adds appropriate methylation providing rapid activation to express the silenced genes
These oncofetal genes are found to be suppressed in adult tissue but due to some retro genetic expression it is found to be expressed again in cells associated with tumor
Summary
Oncofetal genes are those genes which are produced or expressed during development of fetus but are found in adult tissue in very low amount. These oncofetal genes are found to be suppressed in adult tissue but due to some retro genetic expression it is found to be expressed again in cells associated with tumor. Oncofetal antigen when found in adult body can serve as a diagnostic marker in detection and identification of initial progression of oncogenesis [1]. The production of these antigen occur due to activation of certain genes that serve as control genes or by post translational modification. There are many post transcriptional modification in the histone which governs the epigenesist mechanism leading to onco-genesis
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
