Beta-blockers and their impact on blood pressure and heart rate

Abstract

The aim of the study is to determine the impact of beta-blockers on blood pressure and heart rate in patients that use these drugs during treatment of arterial hypertension. The sample included 120 patients from the "Dom Zdravlja'' Živinice. Patients were monitored for 3 years. No statistically significant difference in the values of systolic and diastolic blood pressure as well as heart rate in patients using beta-blockers and other groups of antihypertensives was determined during monitoring period after 12, 24 and 36 months of treatment. Also, there was no statistically significant impact of the applied therapy on these values in the observed time intervals. In order to determine statistically significant difference between treatments, we compared their values sorted by time. No statistically significant difference was found in systolic blood pressure and heart rate between groups, but a statistically significant difference in diastolic blood pressure was found between groups after 12 and 36 months of therapy. No statistically significant difference was found in the values of systolic and diastolic blood pressure, as well as heart rate after 12, 24 and 36 months of treatment by comparing the same values within the group of beta-blockers (patients using bisoprolol and carvedilol and patients using other beta-blockers). Also, there was no statistically significant impact of the applied therapy on the change of these values during observed period. In order to determine statistically significant difference between the treatments, we compared their values sorted by time. There was no statistically significant difference in the values of systolic and diastolic blood pressure and heart rate between the groups. Also, the condition of patients who used beta-blockers in the treatment of hypertension did not require increasing the dose in order to achieve the required parameters. Therefore, in our research, haven't been proven the worse effect of beta-blockers on blood pressure and heart rate when compared to other antihypertensive drugs. Also, all drugs showed equal effectiveness within the group of beta-blockers.