Abstract
Mucoepidermoid carcinoma (MC) constitutes a heterogeneous lesion and may present histologic variations that make the diagnosis difficult to establish. A 45-year-old women presented to a referral center complaining of a 10-year increase of volume in the left posterior mandible, associated with dental displacement, with no sign of oral mucosal involvement. Computed tomography evidenced a large hypodense area, with well-defined limits, cortical bone thinning, and a discrete area of solution of continuity. Incisional biopsy was performed with diagnostic hypothesis of dentigerous cyst or ameloblastoma. Histopathologic analysis revealed a malignant neoplasia with glandular differentiation, presenting a prominent component of large oncocytoid polygonal cells, such as cells with squamous, basaloid, columnar, and mucous aspects. Multiple cystic and ductiform spaces, sometimes containing basophilic mucoid-like material, were observed. Histochemical and immunohistochemical reactions were also performed, and the diagnosis of oncocytic MC was established. Tumor resection and mandibular reconstruction with microsurgical fibular graft were considered for treatment.
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