Abstract
An efficient ‘on water’ direct aldol reaction of oxindoles and β,γ-unsaturated α-keto esters was developed, giving 3-(α-hydroxy-β-carbonyl)oxindoles in high yields (up to 92%) and diastereoselectivities (up to >20:1). Compared with organic solvent, water as the solvent was crucial to the reaction and rate acceleration was observed in water.
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