Abstract
Addition of pyridine, quinoline, niacin, niacinamide, aniline, p-aminobenzoic acid or indole to anaqueous solution of thiamine hydrochloride in the presence of sulphurous acid accelerated the degradation of the thiamine and at the same time caused replacement of the thiazole-portion of the thiamine with the amine. This reaction was affected by pH, and an equilibrium was found when a tertiary amine was employed. It is very interesting to observe that sulphurous acid acts as if it were a thiamine destructive enzyme.
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