Abstract
On June 26, 2000, Celera Genomics and the International Human Genome Sequencing Consortium (HGSC) announced at the White House the completion of the first assembly of the human genome and the completion of a rough draft, respectively. In February of 2001, the two teams simultaneously published their analyses of the genome sequences generated (1, 2). The joint announcement and subsequent publications were a result of long discussions among Celera and HGSC scientists on reducing the negative rhetoric and demonstrating to the public that both teams were working for the public good. Now three laboratory leaders from the public consortium, Waterston, Lander, and Sulston (WLS), argue that Celera did not produce an independent sequence of the human genome or meaningfully demonstrate the whole-genome shotgun (WGS) technique (3). This conclusion is based on incorrect assumptions and flawed reasoning.
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