Abstract
0701 07 1. Evidence is presented that the chromosome of Escherichia coli is non-covalently bonded to a rapidly sedimenting, lipoprotein cellular component. This lipoprotein component is thought to be the cytoplasmic membrane. 2. Two alternative models for the replication of membrane-associated bacterial DNA are presented, accompanied by experimental evidence in support of one of the models. The replication of E. coli DNA is thought to be carried out by a replication complex which is not associated with the cytoplasmic membrane. Instead, the chromosome is attached at one or more sites to the cytoplasmic membrane and is stationary while the mobile replication complex proceeds sequentially during the replication process. 3. A method is described for disrupting the cytoplasmic membrane such that submembrane complexes, containing a fragment of DNA, protein and lipid, are produced. Some of the properties of these complexes have been studied.
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