Abstract

A scheme relating population genetics and TB epidemiology data in Russia is proposed. For this, a genetic susceptibility index is suggested based on relative risk estimates and published data on genetic polymorphisms of various ethnic groups. The index correlates well ( r = 0.746, p < 0.05) with TB morbidity in genetically and geographically distant populations clearly indicating an important role of the genetic component in determining TB epidemiology in Russia.

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