ON THE RELATION BETWEEN URINARY CATECHOLAMINE LEVELS IN PATIENTS WITH HYPERTENSION AND THE REGITINE TEST

Abstract

Catecholamine (adrenalin and noradrenalin) in Urine was estimated in 14 positive reactors to Regitine, 14 false positive reactors and 34 negative reactors by the modified Euler-Floding method of Yoshinaga. In all cases their maximal blood pressure was over 170 mmHg and their minimal pressure was over 90 mmHg. Those who shwoed a decrease of maximal pressure over 35 mmHg as well as of minimal pressure over 25 mmHg by the Regitine administration were regarded as positive reactors, those showing a decrease of maximal pressure over 35 mmHg and of minimal pressure under 25 mmHg were regarded as false positive reactos, and those showing a decrease of maximal pressure under 35 mmHg and of minimal pressure under 25 mmHg were regarded as negative reactors.More adrenalin and noradrenalin in urine were found in the positive reactors than in healthy persons and the negative reactors. But there was found no difference in the amounts of both adrenalin and noradrenaline in urine among the false positive reactors, the negative reactors and healthy persons.The correlation of both adrenalin and noradrenalin to both maximal and minimal blood pressure was not found in the positive and the false positive reactors, though a correlation of noradrenalin to maximal blood pressure was found in the negative reactors.It was concluded that the Regitine test has a close relation to noradrenalin, but not to adrenalin.The positive reactors were found in 11.7% of the 298 examined whose maximal blood pressure was over 170 mmHg.