Abstract
Two years ago I showed that the process of natural fertilization of the sea urchin egg could be imitated by the combination of two agencies: first the artificial production of a membrane around the egg and second the treatment of the egg for some time with hypertonic sea water. I expected that this imitation of the natural process of fertilization by external agencies might lead to a discovery of the ultimate chemical character of the process of fertilization and this proved to be true to that extent that I was able to show in a series of papers, published a year ago, that the essential effect of the natural or artificial fertilization is a calling forth of oxidations in the egg. These oxidations are the prerequisite for the synthesis of nuclein compounds from protoplasmic constituents of the egg, and this synthesis which forms the first stage in the developmental process. It may be that the formation of nucleins is an oxidative synthesis.1When we produce artificially a membrane around the egg by treating...
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