Abstract
SummaryIn experiments on mice, the relation between change in oxygen-tension in the tissue and survival has been studied after administration of thiopental. A decrease in oxygen-tension in all tissues was found. The speed of the decrease in oxygen-tension is dependent on the manner of administration of thiopental and the extent of the reduction on the quantity administered. A reduction in oxygen-consumption and a fall in rectal temperature occurs at the same time as the decrease in oxygen-tension. After intraperitoneal injection of thiopental, the decrease in oxygen-tension reaches a peak in 10 min and thereafter returns to its initial level. During irradiation of the mice at various times after administration of thiopental, radioresistance increases as oxygen-tension is reduced, then decreases as oxygen-tension returns to the initial level. The authors conclude that the radioprotective effect of thiopental is due to the reduction in oxygen-tension.
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