Abstract
Recent advances on the environmental determinants of Kawasaki Disease have pointed to the important role of the atmospheric transport of a still unknown agent potentially triggering the disease. The hypothesis arose from an innovative methodology combining expertise in climate dynamics, the analysis of ocean and atmosphere data, the use of dispersion models and the search for biological agents in air samples. The approach offered a new perspective to reveal the identity of the potential trigger, but at the same time, it increased the level of complexity, which could potentially lead to the misinterpretation of the mechanisms. Some years after it was originally formulated, we here provide a brief clarification on the approach and limits of the methodology in order to prevent an eventual misuse of our research ideas and theory, so that further research can better focus on the knowledge gaps that still remain open.
Highlights
The etiology of Kawasaki Disease (KD) remains unknown after five decades of active research
Recent studies have analyzed the potential connections between KD and a diversity of environmental factors and mechanisms, and among them, important advances have pointed to the relevant role of the atmospheric transport of a still unknown agent triggering the disease
This line of research explored the connections between the temporal components of KD in Japan and nearby sites with those arising from the complex dynamics of tropospheric winds
Summary
The etiology of Kawasaki Disease (KD) remains unknown after five decades of active research. Recent studies have analyzed the potential connections between KD and a diversity of environmental factors and mechanisms, and among them, important advances have pointed to the relevant role of the atmospheric transport of a still unknown agent triggering the disease. This line of research explored the connections between the temporal components of KD in Japan (i.e. the country with the largest incidence) and nearby sites with those arising from the complex dynamics of tropospheric winds.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
