On the influence of water molecules on the outer electronic shells of R–SeH, R–Se(−) and R–SeOH fragments in the selenocysteine amino acid residue

Abstract

The presence of water molecules near the selenocysteine residue in the active centre of the GPx enzyme promotes its antioxidant activity. The 77Se NMR chemical shift is sensitive both to the oxidation and the hydration states of the selenium atom.