Abstract
The anticipated diagnosis of various fatal diseases from the analysis of volatile organic compounds (VOC) biomarkers of the volatolome is the object of very dynamic research. Nanocomposite-based quantum resistive vapor sensors (vQRS) exhibit strong advantages in the detection of biomarkers, as they can operate at room temperature with low consumption and sub ppm (part per million) sensitivity. However, to meet this application they need to detect some ppm or less amounts of biomarkers in patients’ breath, skin, or urine in complex blends of numerous VOC, most of the time hindered by a huge amount of water molecules. Therefore, it is crucial to analyze the effects of moisture on the chemo-resistive sensing behavior of carbon nanotubes based vQRS. We show that in the presence of water molecules, the sensors cannot detect the right amount of VOC molecules present in their environment. These perturbations of the detection mechanism are found to depend on the chemical interactions between water and other VOC molecules, but also on their competitive absorption on sensors receptive sites, located at the nanojunctions of the conductive architecture. This complex phenomenon studied with down to 12.5 ppm of acetone, ethanol, butanone, toluene, and cyclohexane mixed with 100 ppm of water was worth to investigate in the prospect of future developments of devices analysing real breath samples in which water can reach a concentration of 6%.
Highlights
Disease detection and health monitoring by exhaled breath analysis has recently gained huge attention because of its various advantages such as non-invasiveness [1,2,3,4,5,6,7,8,9]
Quantum resistive vapor sensors (QRS) with a PVP matrix were prepared by three different methods to compare the influence of the processing conditions on the chemo-resistive behavior: The first method n◦ 1 (M1) consisted in spraying layer by layer a dispersion of Multi-walled carbon nanotubes (MWCNT) in chloroform (0.4 g·cm−3 ) under sonication with a Bransonic® 3800 (Emerson, Saint-Louis, MO, USA)
In the context of the emerging research field of volatolomics, intending to diagnose various serious diseases such as cancers by the imprint analysis of the Volatile organic compounds (VOC) biomarkers emitted by the body with e-noses, it makes sense to study the impact of water vapor on the sensing behavior of a vQRS matrix
Summary
Disease detection and health monitoring by exhaled breath analysis has recently gained huge attention because of its various advantages such as non-invasiveness [1,2,3,4,5,6,7,8,9]. Exhaled breath contains large amounts of nitrogen, oxygen, carbon dioxide and water vapors, and very small fractions of VOC at the ppm (part per million) to ppb (parts per billion) level. Insatisfies the a the special is paid to the collection of breath andof the is mostly satisfies final objective develop anthe e-nose from the assembly such sensors in but array, theobjective final objective to develop an e-nose from the assembly ofsensors such sensors in array, in but in satisfies theliterature, final to attention develop anto e-nose from assembly of [39,40,41,42] Such indetection array, but done at ppm or ppb concentrations, which more or less satisfies the final objective to develop an e-nose most sensing experiments are alone. In a real the VOC from the assembly of such sensors in array, but in most sensing experiments dispersed in huge amounts of water vapors in breath.
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