Abstract
An electrophoretic study by means of the Tiselius apparatus, was made on the influence of Dicumarol on normal human serum protein fraction.100-150mg of Dicumarl of was administered, orally, for three consecutive days, and the serum protein fractions were compared before and after administration of the drug.Two significant changes were noted.1) A decrease in serum total protein. Although clinically, liver function is said to be unaffected by a therapeutic dose of Dicumarol, it may be that together with the inhibition of the production of prothrombin in the liver, some other factors may be influenced by Dicumarol.2) A decrease in β-globulin. The amount of prothrombin in the blood is only 0.02g/dl. Hence an average decrease of 6.16g/dl as obtained in this experiment cannot be explained solely by decrease in the prothrombin which is associated with the β-globulin. Mann and many other investigators, as opposed to Quick, report that Dicumarol influences other factors than prothrombin. Although we cannot as yet specify the factors involved, this experiment appears to support the former view. It is also reported by Muto et al., that a minute quantity (0.002g/dl) of Heparin causes an increase in the albumin fraction when measured electrophoretically. The explanation given by them is an interaction between the heparin and albumin. However, further experiments are necessary to give a definite conclusion on the cause of the β-globulin decrease, noted in this experiment.
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