Abstract
1. Lithocholic acid-24-14C was administered to rats and labeled hyodeoxycholic acid was isolated from feces and from bile collected after 3 days of intact enterohepatic circulation. Labeled 3α-hydroxy-6-keto-5β-cholanoic acid was isolated from feces. No labeled hyodeoxycholic acid was formed when lithocholic acid-24-14C was administered to bile fistula rats. One of the major metabolites in these experiments was 3α,6β-dihydroxy-5β-cholanoic acid. 2. After administration of 3α,6β-dihydroxy-5β-cholanoic acid-24-14C to intact rats, labeled hyodeoxycholic acid was isolated from feces and bile. Labeled 3α-hydroxy-6-keto-5β-cholanoic acid was isolated from feces. In the bile fistula rat, 3α,6β-dihydroxy-5β-cholanoic acid-24-14C was metabolized mainly into β-muricholic acid and no labeled hyodeoxycholic acid was formed. 3. In the intact rat, 3α-hydroxy-6-keto-5β-cholanoic acid-24-14C was transformed mainly into hyodeoxycholic acid, whereas in the bile fistula rat 3α,6β-dihydroxy-5β-cholanoic acid was the main metabolite. 4. It was suggested that hyodeoxycholic acid is formed from lithocholic acid through the following reactions Lithocholic acid (liver)/→ 3α,6β-dihydroxy-5β-cholanoic acid (intestine)/→ 3α-hydroxy-6-keto-5β-cholanoic acid (intestine)/→ hyodeoxycholic acid
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