Abstract
Possible therapeutic applications of methods of positron annihilation spectroscopy (PAS) with low-energy positron beams are discussed in this review. These methods are used to study the defect structure of material layers of micro- and submicrometer size (surface layers in electronic devices, cell walls and liquid-crystal units in biomedical applications, etc.). We consider a model of analysis with the positron annihilation-lifetime spectroscopy (PALS) method for the states of irradiated membranes of bacterial cells in a cycle of photodynamic therapy, which lies in the destruction or irreversible oxidative damage of pathogenic cells by the photo-inactivated oxygen of a photosensitizer incorporated into the target cell immediately before light exposure.
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