Abstract
The fibrinolytic activity of blood and cerebrospinal fluid (CSF) after pneumoencephalography (PE) has been investigated in ten patients. Samples of blood and CSF were collected and assayed before and 10, 20, 30, and 60 minutes after PE. It was noted that the rise in fibrinolytic activity in CSF preceded the increased fibrinolytic activity which occurred in blood and was of shorter duration. It is suggested that two different mechanisms are involved in the enhancement of fibrinolytic activity in blood and CSF. Injection of air may produce the release of fibrinolytic agents into the CSF from meninges and choroidal plexus which are very rich in plasminogen activator. The stimulation of systemic fibrinolytic activity seems instead mediated by the action of the neurovegetative system.
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