Abstract
On Human Malaria Parasite-Host Relationship, Sterile Immune Response and Cancer
Highlights
International JournalCanc Therapy & Oncol Int J Copyright © All rights are reserved by Filiberto Malagón
When Laveran [1] discovered the malaria parasites, more than 80 years had passed since the application of the first vaccine in 1796 by Edward Jenner against the virus of the small pox [2]
On Laveran’s time researchers were familiarized with vaccines against virus and bacteria, the proposal of a vaccine against Plasmodium to help in the control and care of malaria, would be of general acceptance, with the discovery of the malaria parasites the race for a vaccine had began
Summary
Canc Therapy & Oncol Int J Copyright © All rights are reserved by Filiberto Malagón. Submission: December 21, 2017; Published: January 08, 2018 *Correspondence Address: Filiberto Malagón, Malariology Laboratory, Building A, 2nd floor, Faculty of Medicine, National Autonomous University of Mexico, 04510, Coyoacán, Mexico,Tel: 52 55 56232465; Email: Abstract. Brief semblance on the story of research on malaria vaccine development through the time since the discovery of the malaria parasites to our days is presented, and emphasis on general results obtained is done. The emergence of a purified living sporozoite vaccine attenuated by radiation, and cryopreserved, that promise to control global morbidity and mortality of the malaria in endemic countries, providing sterile immunization against sporozoites of Plasmodium falciparum is commented. Experimental facts on sterile immune state and development of neoplasms when after immunization the antigenic stimulation continues repeatedly are presented. A warning suggestion is made on monitoring the possible augmented oncogenic susceptibility of vaccinated individuals versus the none vaccinated, to evaluate this potential effect of the vaccine
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