Abstract
Free fatty acids (FFA) exert a variety of inhibitory effects on the energy metabolism of mitochondria. They uncouple the oxidative phosphorylation [l-4], inhibit the ATP-Pi exchange [2,3], stimulate the Mg-dependent ATPase [ 1,2] and act as endogenous ionophores for potassium ions [ 51. Moreover, the CoA-esters of fatty acids are strong inhibitors of the adenine nucleotide translocase [6] and the pyridine nucleotide transhydrogenase system [7]. FFA exhibit an instantaneous multi-site inhibition of the electron transport system of non-phosphorylating submitochondrial particles (ETP) which is relieved or prevented by serum albumin [8,9]. In this report a new inhibitory effect of FFA is described which appears slowly.
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