Abstract
In uptake and retention studies, the biosystem can often be thought of as comprising K distinct compartments with constant rates of passage of particles from any compartment to a different compartment. Before the theoretical uptake and retention curve for any compartment can be plotted and compared with the experimentally determined curve for the same compartment, it must be possible to estimate these rates from the data of the experiment. A mathematical model of such a system is deduced which is sufficiently general to comprehend both the chronic and acute feeding situations. A method is presented for estimating the migration rate constants. If Xi, denotes the theoretical constant rate of migration of particles from region i to region j, and Xii denotes an estimate of Xii calculated from the experimental data, then it is shown that
Published Version
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