СOMPLEXES OF Nd(III) AND 3d-METALS BASED ON ETHYLENEDIAMINEDISUCCINIC ACID AS POTENTIAL ANTIFUNGAL AGENTS

Abstract

Neodymium heterometallic complexes [(NdМIIEDDS)(H2O)6]∙n2H2O (МII=Zn, Co; n = 3; 2) were synthesized by the «block» synthesis method using protonated ethylenediaminedisuccinate of the 3-d metal and NdIII nitrate. The complexes were characterized by spectroscopic methods (UV-VIS electronic absorption spectroscopy and FT-IR) and elemental ana­lysis. It is shown that the f-d-complexes belong to the «folded» type complexes, in which the ligand-EDDS realizes the maximum dentateness to NdIII, and the coordination sphere of the 3-d cation is formed by chain carboxyl groups of EDDS and intraspherical water molecules. At the same time, the cations of 3d metals are in a distorted octahedral environment, and the coordination polyhedron of the neodymium ion corresponds to a square antiprism (C4v) with the coordination number NdIII = 8. In solutions and in the solid state, the complexes have the same type of structure. The sensitivity of various morphological forms of Candida albicans in Spider and Saburo media to neodymium complexes NdIII with ethylene diamine disuccinate: NdEDDS (I), NdEDDSZn (II) NdEDDSСo (III) in the range of concentrations of the studied compounds 1; 10 and 100 μM was studied. It is shown that the antifungal properties of the complexes vary in the range NdEDDSСo> NdEDDSZn ≥ NdEDDS. The inhibition index of C. albicans in the composition of the biofilm in the Saburo medium under the action of the complexes was 20–25% of the control value, and in the Spider medium the complexes led to 95% of cell death.