Abstract
Purpose of the study. To assess changes in the comple-ment system in oncopathology (C3 (H2O) level, C1q-IgG dissociation constant) and the effect on these indicators of a complex preparation of 3d-metal gluconates (Mn, Fe, Co, Cu and Zn). It has been shown that in oncopathology (NHL, CL, BC) during incubation of blood serum, there is a change in the nature of the transition of the C3 component of the complement into its hydrolysis form C3 (H2O) and an in-crease in the dissociation constant of the C1q-IgG com-plex. After therapy with a complex preparation of 3d-metal gluconates, a correction of the C3 (H2O) level was observed. Treatment in myeloma mice had a similar effect on the hydrolysis curve of the C3 component and led to a decrease in the C1q-IgG dissociation constant. The use of these complement indicators may be promising for assessing the effectiveness of therapy.
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