Omic characterization of the endothelial model mimicking glucose variability

Abstract

Background and Aims : Glycemic variability (GV), a complex phenomenon affecting subjects with diabetes, is one of the main contributors to the risk to develop both acute and long-term complications in type 1 (T1D) and type 2 (T2D) subjects. The characteristic cellular phenotype induced by GV is scarcely defined. Aims of this study are: 1) to describe a global pattern about the regulation of the major proteins differentially expressed in a cellular (human endothelial cells) model of GV and 2) the role of microRNAs on the pathways activated during the in-vitrolong-term exposures to GV.