Abstract
Purpose:To investigate the role of omeprazole and nitrites on the gastric mucosa of rats submitted to specific techniques to induce duodenogastric reflux.Methods:One hundred and twenty Wistar rats were divided into three groups: Group I (n=40) -gastrotomy; Group II (n=40) - duodenogastric reflux after gastrojejunoanastomosis latero-lateral (DGR); Group III (n=40) - retrograde duodenogastric reflux through the pylorus (DGR-P). The groups were divided into 4 subgroups of 10 animals, respectively treated for 16 weeks with water, omeprazole 1.6 mg / rat / day, nitrite 600 mg / kg / day and omeprazole plus nitrite simultaneously.Results:The proliferative lesions found were: squamous hyperplasia - 69.1%, adenomatous hyperplasia in the anastomosis - 29.1% and prepyloric adenomatous hyperplasia - 42.5%. Adenocarcinomas were registered in 7 animals (5.8%): one in Group I (omeprazole plus nitrite), two in Group II (omeprazole and nitrite plus omeprazole) and four in Group III (water, nitrite, omeprazole and omeprazole plus nitrite).Conclusions:The occurrence of squamous hyperplasia, adenomatous hyperplasia and adenocarcinoma increased after gastrojejunal anastomoses, which cause duodenogastric reflux. The association of omeprazole did not protect the development of proliferative lesions and cancer induced by duodenogastric reflux in rats.
Highlights
ObjectivesThe aim of this study was to investigate the effects of omeprazole and nitrites on the gastric mucosa of rats submitted to duodenogastric reflux
The occurrence of squamous hyperplasia, adenomatous hyperplasia and adenocarcinoma increased after gastrojejunal anastomoses, which cause duodenogastric reflux
Some local effects of prolonged use of pump inhibitor (PPI)’s have been recorded, such as atrophic gastritis, chronic Helicobacter pylori infection, hypergastrinemia, and development of gastric polyps resulting from prolonged acid suppression, which have led to concerns about the increased risk for gastric cancer[2,3,4]
Summary
The aim of this study was to investigate the effects of omeprazole and nitrites on the gastric mucosa of rats submitted to duodenogastric reflux
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