Abstract
The relationship of visceral obesity and excess body weight (EBW) with the development of cardiovascular diseases, type 2 diabetes mellitus (DM) and effect on quality and duration of life determine the relevance of studying this problem. The aim: to assess omentin-1 metabolism and pathophysiological relationship between its level and the severity of lesions in the intima-media thickness (IMT) of the carotid arteries in type 2 DM in combination with EBW and obesity. Materials and methods. We examined 98 people with DM, the first group consisted of 64 people with EBW and obesity, second group consisted of 34 people with normal body weight, control group – 28 healthy individuals. The concentration of omentin-1 was investigated by ELISA by solid-phase enzyme-linked immunosorbent assay in vitro. Ultrasound of the carotid arteries was performed in the lying position of the patient on the device MyLab50X with a linear sensor of 7 MHz with a slight deviation of the patient's head in the opposite direction. Results. Evaluation of the correlation matrix showed the presence of a positive rather strong negative connection between IMT, especially the right carotid artery and the level of omentin-1 in the blood (Rs = –0.55; p = 0.002). The largest number of individuals with omentin-1 levels from 5–10 ng / ml had significant disorders of the vascular wall (IMT from 1.0 to 1.2 mm). Conclusion. Obtained data indicate a statistically significant associative relationship between the dynamics of the predictor of cardiovascular risk – IMT with the degree of impaired expression of omentin-1.
Highlights
OMENTIN METABOLISM ANDThe relationship of visceral obesity with the development of cardiovascular disease, type 2 diabetes mellitus (DM), as well as the impact of obesity and PATHOPHYSIOLOGICAL RELATIONSHIP BETWEEN ITS LEVEL AND THE SEVERITY OF LESIONS IN THE INTIMA-MEDIA THICKNESSOF THE CAROTID ARTERIES IN98 people with DM were examined, who were inpatient treatment in the KI “RK Endocrine Dispensary” ZRC in 2017–2020
The results show that patients of the first group with type 2 DM and obesity had the lowest levels of omentin-1 – 8.08 ng/ml compared to patients of the second group who were not obese and especially for relatively healthy people in the control group – 21.08 ng/ml
Overweight and obesity led to a significant decrease in serum omentin-1 in patients of the first group, which, in turn, leads to increased insulin resistance and worsening of type 2 DM, as well as activation of pathogenetic chain mechanisms of cardiovascular damage and a number of concomitant metabolic changes
Summary
OMENTIN METABOLISM ANDThe relationship of visceral obesity with the development of cardiovascular disease, type 2 diabetes mellitus (DM), as well as the impact of obesity and PATHOPHYSIOLOGICAL RELATIONSHIP BETWEEN ITS LEVEL AND THE SEVERITY OF LESIONS IN THE INTIMA-MEDIA THICKNESSOF THE CAROTID ARTERIES IN98 people with DM were examined, who were inpatient treatment in the KI “RK Endocrine Dispensary” ZRC in 2017–2020. The relationship of visceral obesity with the development of cardiovascular disease, type 2 diabetes mellitus (DM), as well as the impact of obesity and PATHOPHYSIOLOGICAL RELATIONSHIP BETWEEN ITS LEVEL AND THE SEVERITY OF LESIONS IN THE INTIMA-MEDIA THICKNESS. The second group consisted of 34 people (19 women and 15 men) with normal body weight (body mass index ≤25 kg/m2), the average age was 55.6±11.92 years, the duration of DM was 6.5±5.70 years Thickening of in the intima-media thickness (IMT) of the carotid arteries in have been followed and conductthe intima-media is associated type 2 DM in combination with EBW and obesity
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