Abstract
Mounting evidence indicates an association between adipokines and inflammation-related atherosclerosis. Here, we sought to investigate the association of vaspin and omentin with clinical characteristics and outcomes of patients with acute cerebral ischemia (ACI). Consecutive ACI patients were evaluated within 24 h from symptom-onset. Stroke aetiology was classified using TOAST criteria. Adipokines were assayed using quantikine enzyme immunoassay commercially available kits. Stroke severity was assessed by NIHSS-score, and ipsilateral carotid stenosis (≥50% by NASCET criteria) by ultrasound and CT/MR angiography. Major cerebrovascular events were assessed at three months. We included 135 ACI patients (05 (78%) and 30 (22%) with acute ischemic stroke and transient ischemic attack, respectively; mean age ± SD: 59 ± 10 years; 68% men; median NIHSS-score: 3 (IQR:1–7)). Omentin was strongly correlated to admission stroke severity (Spearman rho coefficient: +0.303; p < 0.001). Patients with ipsilateral carotid stenosis had higher omentin levels compared to patients without stenosis (13.3 ± 8.9 ng/mL vs. 9.5 ± 5.5 ng/mL, p = 0.014). Increasing omentin levels were independently associated with higher stroke severity (linear regression coefficient = 0.290; 95%CI: 0.063–0.516; p = 0.002) and ipsilateral carotid stenosis (linear regression coefficient = 3.411; 95%CI: 0.194–6.628; p = 0.038). No association of vaspin with clinical characteristics and outcomes was found. Circulating omentin may represent a biomarker for the presence of atherosclerotic plaque, associated with higher stroke severity in ACI patients.
Highlights
Increasing attention has been drawn recently towards the establishment of bloodbased biomarkers for acute ischemic stroke (AIS) and their incorporation into diagnostic and prognostic AIS models [1,2]
Our study showed that during the early phase of acute cerebral ischemia (ACI), increasing omentin levels are independently associated with increasing age, higher stroke severity and ipsilateral carotid artery stenosis in patients presenting within 24 h from ACI symptom onset
Circulating omentin did not appear associated with underlying stroke aetiologies according to TOAST classification, significantly higher omentin levels were measured in patients with moderate or severe (≥50%) ipsilateral carotid artery stenosis compared to patients without evidence of carotid artery disease
Summary
Increasing attention has been drawn recently towards the establishment of bloodbased biomarkers for acute ischemic stroke (AIS) and their incorporation into diagnostic and prognostic AIS models [1,2]. As the timing of measurement has been acknowledged as a key factor when interpreting results of biomarker research [3,18], the potential diagnostic and prognostic yield of adipokines during the early phase of stroke remains to be established. In view of the former considerations, we sought to investigate potential associations of circulating omentin and vaspin levels during the early phase of ACI with clinical and neuroimaging characteristics and outcomes of patients presenting within 24 h from
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