Abstract
Method We conducted a randomized, double-blinded, placebo controlled, crossover trial on an overweight middle aged male population at risk of developing the metabolic syndrome comparing olive leaf extract containing 51 mg oleuropein and 9.7 mg hydroxytyrosol to placebo. We measured insulin sensitivity (Matsuda method), pancreatic b-cell responsiveness (oral disposition index), lipid profile, ambulatory blood pressure, carotid intimal media thickness, body composition (DEXA) basal metabolic rate, hand-grip strength, wellness questionnaire, inflammatory cytokines, antioxidant potential all measured at baseline and end of both interventions.
Highlights
Olive leaf extract improves insulin sensitivity in overweight middle aged males
We measured insulin sensitivity (Matsuda method), pancreatic b-cell responsiveness, lipid profile, ambulatory blood pressure, carotid intimal media thickness, body composition (DEXA) basal metabolic rate, hand-grip strength, wellness questionnaire, inflammatory cytokines, antioxidant potential all measured at baseline and end of both interventions
Even after controlling for total calorie intake fibre intake, physical activity, age, and percentage body fat (DEXA), insulin sensitivity was significant improved on treatment Vs placebo (19% p=
Summary
Olive leaf extract improves insulin sensitivity in overweight middle aged males. This is applicable to an overweight adolescent population. Olive leaf extract improves insulin sensitivity in overweight middle aged males; a randomized, double-blinded, placebo controlled, crossover trial Martin de Bock*, Jose Derraik, Christine Brennan, Eric Thorstensen, Wayne Cutfield†
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