Abstract
In neuroendocrine cells, hormones and neuropeptides are released from large-dense core vesicles (secretory granules) by calcium-regulated exocytosis. Following exocytosis, compensatory uptake of membrane is required to maintain membrane homeostasis and allow recycling of secretory vesicle membranes. How these cells initiate and regulate this compensatory endocytosis remains poorly understood. Our recent data suggests that oligophrenin-1 (OPHN1) is a link coupling calcium-regulated exocytosis to compensatory endocytosis of secretory granules in the adrenal chromaffin cells (Houy et al., 2015, J Neurosci. 2015, 35:11045-55). Here, we highlight the major evidence and discuss how OPHN1 could couple these two processes.
Highlights
Intracellular membrane trafficking along endocytotic and secretory pathways plays a critical role in diverse cellular functions including developmental and pathological processes
We demonstrated that overexpression of OPHN1 mutant lacking the BAR domain reproduced the inhibitory effect on granule membrane recapture in bovine chromaffin cells whereas the GTPase activating protein (GAP)-dead OPHN1R409L mutant had no effect
Oligophrenin-1 is a molecular switch between exocytosis and endocytosis of secretory granules
Summary
Oligophrenin-1: the link between calcium-regulated exocytosis and compensatory endocytosis in neuroendocrine cells. Hormones and neuropeptides are released from large-dense core vesicles (secretory granules) by calcium-regulated exocytosis. Compensatory uptake of membrane is required to maintain membrane homeostasis and allow recycling of secretory vesicle membranes. How these cells initiate and regulate this compensatory endocytosis remains poorly understood. Our recent data suggests that oligophrenin-1 (OPHN1) is a link coupling calcium-regulated exocytosis to compensatory endocytosis of secretory granules in the adrenal chromaffin cells To cite this article: Catherine Estay-Ahumada, et al Oligophrenin-1: the link between calcium-regulated exocytosis and compensatory endocytosis in neuroendocrine cells.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have