Oligodendrocytes in Schizophrenia

Haiyun Xu,Martha E Shenton,Vahram Haroutunian,George Bartzokis

doi:10.1155/2011/249768

Abstract

Oligodendrocytes in Schizophrenia

Highlights

The second paper focuses on altered neuronal connectivity
The primary aim of this special issue is to understand and to clarify further white matter pathology in schizophrenia and how it may contribute to disconnectivity among brain regions, which results in the observed cognitive, behavioral, and clinical symptoms in this disorder
As white matter is the main infrastructure for brain connectivity, this paper focuses on the use of a magnetic resonance imaging (MRI) technique called diffusion tensor imaging (DTI) to gain insight into the role of white matter abnormalities in schizophrenia

Summary

Introduction

The second paper focuses on altered neuronal connectivity. Here, the focus is on altered connectivity and impaired myelination in a postmortem study of schizophrenia and normal controls, where electron microscopy is used to study myelinated fibers and oligodendrocytes. Haiyun Xu,1 Vahram Haroutunian,2 George Bartzokis,3 and Martha E. A focus on white matter connections in the brain has become increasingly of interest in schizophrenia, in the areas of imaging studies, postmortem studies, and new animal models of schizophrenia.

Results

Conclusion