Abstract
Two or 3 discrete γ-bands were found in 6 of 10 hydrosoluble multiple sclerosis (MS) brain protein preparations when investigated by agar gel electrophoresis. Immunoglobulin G (IgG) was isolated from hydrosoluble brain protein preparations by ion exchange chromatography and subsequent gel filtration. The discrete γ-bands were recovered on agar gel electrophoresis of IgG isolated from MS brains, indicating that MS brain might contain oligoclonal IgG. Significantly increased concentrations of the immunoglobulins G and A, and a significantly different distribution of these 2 immunoglobulins to albumin were found in MS brains compared with control brains. No immunoglobulin abnormalities were demonstrable on investigation of CSF and hydrosoluble brain proteins from 2 cases with Creutzfeldt-Jakob's disease. The difference is emphasized concerning the occurrence of immunoglobulin abnormalities within the central nervous system in MS, where a viral aetiology has been proposed, and in Creutzfeldt-Jakob's disease, which is caused by a slow virus infection.
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