Abstract
Olfactory neuroblastoma (ON) is a rare tumour of the olfactory neuroepithelium that is characterized by a pattern of slow growth and local recurrences. Combination of surgery and radiotherapy, with or without chemotherapy, is considered to be the standard of care for primary site disease. Recent literature supports the view that endoscopic resection followed by adjuvant radiotherapy correlates with better outcome. In this short communication, we present a case report of olfactory neuroblastoma arising in the right nasal sinus in a 34-year-old male. This patient was treated with endoscopic resection and external beam radiotherapy to the right nasal sinus with intensity-modulated radiation therapy (IMRT) technique. After 2 years follow-up, the patient is free of tumour without any late effect related to therapies. We believe that, in such patients, a treatment strategy including endoscopic resection followed by adjuvant radiotherapy may be effective and feasible and should be considered the gold standard of care.
Highlights
Olfactory neuroblastoma (ON) originates from the olfactory epithelium
We report the case of a patient with a mass in the right nasal cavity who was treated by endoscopic resection and adjuvant RT
After discussion in the multidisciplinary tumour board, a bimodality therapeutic approach consisting of endoscopic resection followed by adjuvant radiotherapy (RT) was chosen
Summary
Olfactory neuroblastoma (ON) originates from the olfactory epithelium. Unilateral nasal obstruction and epistaxis are the most common symptoms. Treatment modalities for ON are surgery combined with radiotherapy (RT) and/or chemotherapy.[1] In this short communication, we report the case of a patient with a mass in the right nasal cavity who was treated by endoscopic resection and adjuvant RT. MRI was performed, revealing a wellcircumscribed lesion in the right nasal sinus, hypointense on T1 weighted and hyperintense on T2 weighted sequences (Figure 1). This disease presentation corresponded to Kadish stage B. Dose–volume histogram was calculated for the IMRT plan for the following volumes: PTVs, spinal cord, brainstem, optic chiasm, eyes, optic nerves and lens. Axial (a, b), coronal (c) and sagittal (d) views of target volumes: inner lines correspond to clinical target volume, whereas outer lines represent planning target volume nasal endoscopy; after 2 years of observation, he continues to be free from disease without any late complications of therapy
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