Abstract
A liquid chromatographic separation and selective post-column derivatization of six β-aminothiols with o-phthalaldehyde is reported. The presence of both primary amine and thiol functional groups in these compounds makes it possible to derivatize with o-phthalaldehyde alone, eliminating the need for external thiol addition. The structures of the fluorescent derivatives formed in this procedure were determined by off-line liquid chromatography—gas chromatography—mass spectrometry. Spectral fluorescence characteristics for the β-aminothiol- o-phthalaldehyde derivatives are also reported.
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