Abstract
Wound healing is characterized by acute inflammation, granulation tissue formation, and scar tissue formed by remodeling. The process of wound repair during injury, whether traumatic or surgical, is paramount to human survival. Platelet-derived growth factor (PDGF) is considered one of the principal growth factors appearing on the wound surface. Growing evidence has shown that PDGF contributes to wound repair by attracting and stimulating the proliferation of wound-healing cells. In vitro studies have indicated that PDGF is chemotactic for neutrophils, monocytes, and fibroblasts.
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