Abstract
In the recent past, sequencing of ancient human genomes has become increasingly common, leading to an immense amount of data to be explored. For this study we focused on comparing a set of ancient individuals with modern populations on behalf of markers for celiac disease. We analyzed a panel of 64 SNPs related to this disease, trying to detect changes in allele frequencies between ancient and modern individuals. We hope to make a contribution to the subject of genetic health throughout human history.
Highlights
The sprout to pre-eminenceCereals, wheat, are a mainstay of traditional western diets
For this study we focused on comparing a set of ancient individuals with modern populations on behalf of markers for celiac disease
The results of our data analysis provide a good overview of a wide spectrum of changes in allele frequencies for 64 SNPs connected to celiac disease (Figure 1) and their combined risk score for representative individuals (Figure 2)
Summary
The sprout to pre-eminenceCereals, wheat, are a mainstay of traditional western diets. Modern wheat kernels consist to 70 to 75 percent of proteins, divided into glutenin and gliadin which can form several polymers summarized under the term “gluten” [1]. They all share a unique amino acid composition with a high content of glutamine and proline and only low contents of amino acids with charged side groups [2]. The last 50 years have seen a rate of increase in wheat consumption that is higher than for any other cereal During this period in the United Kingdom, an average of 50% of the total carbohydrates consumed by individuals derived from cereals [4]. The roots of wheat as a major source for carbohydrates stretch back much farther, to about 12500 years (BP), and the beginning of the Neolithic period [5]
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