Abstract
SUMMARY Two non-traumatic methods for the induction of deciduomata were tested in the pseudopregnant mouse. The intra-uterine injection of arachis oil was found to be very effective, but the intraperitoneal injection of pyrathiazine was completely ineffective. Oil and trauma were then compared as decidual stimuli in ovariectomized pseudopregnant mice maintained on exogenous progesterone. When ovariectomy was performed on the afternoon of day 4 of pseudopregnancy both stimuli were effective. When the ovaries were removed on the afternoon of day 3, trauma was still effective but oil no longer induced deciduomata. However, oil retained its effectiveness if 0·025 μg. of oestradiol was injected subcutaneously about 7 hr. before the injection of the oil. It is suggested that the hormonal requirements for decidual cell-induction by oil are similar to those for implantation and that oestrogen is necessary to permit the initial reaction between the oil (or the blastocyst) and the surface of the epithelial cells. Traumatic induction does not require oestrogen because it does not simulate this reaction.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
