Abstract
Summary. This study concerns the histochemical demonstration of cyclic 3′,5′-adenosine monophosphate phosphodiesterase (cAMP-PD) and 5′-nucleotidase in the cervicovaginal epithelium of neonatal mice. Newborn animals showed no demonstrable activity of either of the enzymes; some cAMP-PD activity was present in 3-day-old animals, but no 5′-nucleotidase activity was seen at this age. Oestradiol-17β promoted an increased activity of both enzymes in 3-day-old animals. The localization of both enzymes was probably adjacent to the plasma membrane, with an increased activity at the luminal surface. This investigation has shown that cAMP-degrading enzymes are present in this tissue and that the `action mechanism' of oestradiol involves an effect on the cAMP-level regulating system.
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