Abstract
SummaryLimbal stem cells insufficiency (LSCI) can be primary (PLSCI) or secondary. (SLSCI). LSCI can be total or partial. Sings and symptoms of LSCI are: decreased visual acuity, photophobia, pain, and corneal epithelial defects leading to the loss of transparency. Conjunctivilzation of the cornea is a symptom sine qua non of total SLSCI. 5–15% cases of SLSCI are after contact lenses wearing. The LSCI in long term contact lens wearers is caused by oxygen level reduction, mechanical irritation and / or inflammatory etiology of corneal limbus. Treatment includes the use of topical corticosteroids, cyclosporin A application of preservative free artificial tears eye drops. Surgical treatment includes: the autologous or allograft limbal stem cell transplantation. Autologous cultured limbal stem cell transplantation is a new method with standardized number of transplanted limbal stem cells. All surgical options of treatment will be discussed.
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