Abstract
Aim:The aim of this study was to investigate 10 cases of bovine ocular squamous cell carcinoma (OSCC) diagnosed in Holstein or Holstein-crosses cows.Materials and Methods:The investigation was performed exclusively in OSCC cases diagnosed in the State of Paraná and Santa Catarina. A combination of two previously existing histopathological classifications systems was used. The tissue samples were tested for immunoexpression of p53 and p16 and polymerase chain reaction (PCR) for bovine herpesvirus and papillomavirus.Results:A positive correlation between number of mitotic figures and tissue invasion was found. Anaplasia parameters did not correlate well with tumor invasion of deeper tissues and mitotic counts. Six of 10 OSCC cases were in animals with heavily pigmented eyes. Immunoexpression of p53 and p16 was observed in 3 cases each. Bovine herpesvirus and papillomavirus were not detected by PCR.Conclusions:Our results indicate that OSCC occurrence is most likely multifactorial with genetic, phenotypic, and environmental influences contributing to the pathogenesis of the disease.
Highlights
Ocular squamous cell carcinoma (OSCC or “cancer eye”) has been recognized in the literature since the latter part of the 19th century [1]
The tissue samples were tested for immunoexpression of p53 and p16 and polymerase chain reaction (PCR) for bovine herpesvirus and papillomavirus
Six of 10 ocular squamous cell carcinoma (OSCC) cases were in animals with heavily pigmented eyes
Summary
Ocular squamous cell carcinoma (OSCC or “cancer eye”) has been recognized in the literature since the latter part of the 19th century [1]. It is a primary neoplasm of epithelial origin that may occur in different ocular and periocular tissues including the palpebral skin, epithelial surfaces of the cornea and conjunctiva, third eyelid, and limbus. The reported incidence of OSCC in European countries is lower than in Africa and the Americas [4]. OSCC occurs in other farm animal species including sheep, swine, goats, and horses but with a lower incidence [5]
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