Abstract
Bovine Ocular Squamous Cell Carcinoma is considered the most common bovine tumour, causing significant economic losses, mainly by abattoir condemnations. To obtain a better insight into the genesis and neoplastic transformation, 19 samples collected at slaughter from Holstein Friesian cattle and diagnosed as Ocular Squamous Cell Carcinoma were studied. Tumours were histologically classified into three categories: poorly (26.3%), moderately (26.3%), and well differentiated (47.4%). Expression of keratins (MNF116 and LP34) and of cornified envelope precursors (involucrin and profilaggrin) was studied. Expression of MNF116 was observed in all carcinomas. LP34 immunostaining was seen in all but three carcinomas, one from each degree. Involucrin immunoreaction was observed in all but one poorly differentiated carcinoma. Profilaggrin was present in only two moderately differentiated carcinomas, in all but one well differentiated, and in all but one poorly differentiated. MNF116 is a useful marker to confirm the epithelial origin of the tumour and stain most neoplastic cells in these tumours. The expression of involucrin and LP34 demonstrates that, in all tumours, cells have reached the final program of differentiation, regardless of the grade. The expression of profilaggrin could indicate molecular changes during malignant transformation but their expression does not seem to be of diagnostic value.
Highlights
Ocular Squamous Cell Carcinoma (OSCC) is a general designation for a group of primary neoplasms of keratinocytes emerging from ocular tissues, especially the eyelids and the third eyelid [1]
The results obtained with LP34 are in line with studies performed in humans, which report a positive reaction only in squamous cells surrounding the keratin pearls [29,48]
As may be evaluated from the results of the present work, simple tumour morphology may be insufficient to corroborate the classification of the Bovine Ocular Squamous Cell Carcinoma (BOSCC) degrees, as absence of staining with this antibody was obtained in a moderately differentiated (MD) tumour, and in a well differentiated (WD) tumour
Summary
Ocular Squamous Cell Carcinoma (OSCC) is a general designation for a group of primary neoplasms of keratinocytes emerging from ocular tissues, especially the eyelids and the third eyelid [1]. Bovine Ocular Squamous Cell Carcinoma (BOSCC) has been diagnosed all over the world with high incidence, and it is considered the most common bovine tumour and the one which causes the most significant economic losses, mainly by abattoir condemnations [1,2,3,4,5,6,7,8]. This tumour is described mostly in aged animals from Hereford and Holstein or derived breeds, among others [1,2,4,5,8]. Miguel Island, large numbers of cattle affected with OSCC are rejected for consumption at slaughter and OSCC is the second most frequent neoplasia, after urinary bladder tumours, representing
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