Abstract
The ocular and cerebral blood flow response to variations in arterial blood pCO2 levels was studied with the microsphere method in 10 newborn piglets. Surgery was performed under nitrous oxide anesthesia. The animals were then given pancuronium and ventilated for 1h at normal blood gas values. Measurement of blood flow and cardiac output (CO) were done at 5 previously determined pCO2 levels. Hypocarbia always preceded hypercarbia. Results were: The results show that in contrast to CBF, OBF is little affected by variations in arterial pCO2 levels. These results differ from studies in spontaneously breeching piglets, and indicate that OBF may be regulated independently of CBF. Pancuronium and/or artificial ventilation may also influence upon this regulation.
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