Abstract
Oceanapia magna Santos-Neto, Nascimento, Cavalcanti and Pinheiro sponges are distributed across tropical worldwide seas. Some studies of marine products have shown interesting activities in smooth muscle models. Hence, we assessed the effect of the ethanolic extract of Oceanapia magna. (OC-EtOH) on acute toxicity and gastrointestinal motility (in vitro and in vivo) in rodent models. On guinea pig ileum, OC-EtOH induced a concentration dependent contraction on basal tonus, which was not inhibited by atropine, but in the presence of pyrilamine or verapamil, the effect was antagonized. Contrastingly, on KCl- or histamine-induced contractions, OC-EtOH presented a transient contraction followed by a concentration-dependent relaxation. Moreover, OC-EtOH presented a relaxant profile on cumulative curves to CaCl2 and tonic contraction induced by S-(-)-BayK8644, through Cav blockade. The acute toxicity assay showed that OC-EtOH (2,000 mg/kg, p.o.) did not present any sign of toxicity in female mice. Additionally, OC-EtOH presented antidiarrheal effect in mice, increased the intestinal normal transit and reduced the castor oil-induced intestinal transit. Thus, OC-EtOH presented a dual effect on guinea pig ileum promoting contraction through activation of H1 and CaV, and relaxation through CaV blockade, besides the effect on upper gastrointestinal transit in mice, showing a potential medicinal use of this sponge in intestinal diseases such as diarrhea.
Highlights
Natural products are considered a natural library of combinatorial chemistry that can provide substances with chemical and pharmacological diversity (Wang et al, 2011)
The ethanolic extract obtained from Oceanapia magna sponge (OC-EtOH) was used in this study
The effects of ethanolic extract obtained from Oceanapia magna. sponge (OC-EtOH) were investigated on rodents’ intestinal smooth muscle
Summary
Natural products are considered a natural library of combinatorial chemistry that can provide substances with chemical and pharmacological diversity (Wang et al, 2011). Dual Effect of Oceanapia magna Sponge are interested in studying natural marine products due to the varied production of compounds that may be used to treat various diseases (Movahhedin et al, 2014). Marine natural products are sources of compounds that have demonstrated a plethora of biological activities, in both preclinical and clinical research, such as antifungal (D’auria et al, 2007), anticoagulant (Jung et al, 2007), antibacterial (Horie et al, 2008), anti-inflammatory (Chao et al, 2008), immunomodulatory (Yamada et al, 2007; Courtois et al, 2008), antiviral (Artan et al, 2008) and anticancer (Malyarenko et al, 2018; Rath et al, 2018). Oceanapia species produce different classes of metabolites, including alkaloids, sphingolipids, steroids, acetylene, thiocyanate, among others (Ibrahim et al, 2013) that showed antifungal effect (Nicholas et al, 1999) and anticancer activity (Kijjoa et al, 2007)
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