Abstract
Gastric pentadecapeptide BPC 157 therapy counteracts multiple organ dysfunction syndrome in rats, which have permanent occlusion of the superior mesenteric artery close to the abdominal aorta. Previously, when confronted with major vessel occlusion, its effect would rapidly activate collateral vessel pathways and resolve major venous occlusion syndromes (Pringle maneuver ischemia, reperfusion, Budd–Chiari syndrome) in rats. This would overwhelm superior mesenteric artery permanent occlusion, and result in local, peripheral, and central disturbances. Methods: Assessments, for 30 min (gross recording, angiography, ECG, pressure, microscopy, biochemistry, and oxidative stress), included the portal hypertension, caval hypertension, and aortal hypotension, and centrally, the superior sagittal sinus hypertension; systemic arterial and venous thrombosis; ECG disturbances; MDA-tissue increase; and multiple organ lesions and disturbances, including the heart, lung, liver, kidney, and gastrointestinal tract, in particular, as well as brain (cortex (cerebral, cerebellar), hypothalamus/thalamus, hippocampus). BPC 157 therapy (/kg, abdominal bath) (10 µg, 10 ng) was given for a 1-min ligation time. Results: BPC 157 rapidly recruits collateral vessels (inferior anterior pancreaticoduodenal artery and inferior mesenteric artery) that circumvent occlusion and ascertains blood flow distant from the occlusion in the superior mesenteric artery. Portal and caval hypertension, aortal hypotension, and, centrally, superior sagittal sinus hypertension were attenuated or eliminated, and ECG disturbances markedly mitigated. BPC 157 therapy almost annihilated venous and arterial thrombosis. Multiple organ lesions and disturbances (i.e., heart, lung, liver, and gastrointestinal tract, in particular, as well as brain) were largely attenuated. Conclusions: Rats with superior mesenteric artery occlusion may additionally undergo BPC 157 therapy as full counteraction of vascular occlusion-induced multiple organ dysfunction syndrome.
Highlights
We have focused on the superior mesenteric artery occlusion and the stable gastric pentadecapeptide BPC 157
Illustrating the rapid onset of the beneficial effect, grossly, considerable brain swelling is rapidly reversed upon BPC 157 application, and brain lesions markedly attenuated
The observed therapy effect in the severely affected rats with an occluded superior mesenteric artery was a strong one as noted before in the Pringle maneuver, ischemia, reperfusion, and Budd–Chiari-syndrome [24,25] and other vessel occlusion studies [18,19,21,22,23]. To support this common conclusion, it should be noted that whatever may be the particular difference between the venous occlusion (Pringle maneuver, ischemia, reperfusion, and Budd–Chiari-syndrome) [24,25] and artery occlusion, multiple organ dysfunction syndrome shares a similar rapid onset and widespread presentation, and corresponds to each other
Summary
We have focused on the superior mesenteric artery occlusion and the stable gastric pentadecapeptide BPC 157. Confronted with major vessel occlusion [18,19,20,21,22,23,24,25], its effect rapidly activated collateral vessel pathways and re-established blood flow [18,19,20,21,22,23,24,25]. We hypothesized that this effect would overwhelm superior mesenteric artery permanent occlusion, and consequent local, peripheral, and central disturbances. As a cytoprotective agent [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17], and a likely mediator of Robert’s cytoprotection [26], BPC 157 shows its effectiveness in the whole gastrointestinal tract, and counteracts various lesion models, exhibiting a particular effect on blood vessels [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17]
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