Abstract
Abstract Background and aim: Sepsis is a severe complication in cardiac surgery, but data on new therapies are inconclusive and new tretments are warranted. Coupled plasma filtration adsorption (CPFA) is a new extracorporeal technology which combines plasma filtration and ultrafiltration. The aim of this study is to evaluate in septic patients submitted to CPFA: Methods: Overall coohort study and a propensity–matched analysys included 96 patients admitted to three ICU with a diagnosis of septic shock. 73 patients were submitted to CPFA and 23 patients to RRT. In the CPFA group Heparine ev was used as anticoagulant in 22 patients and citrate in 11. In the RRT group Heparine was used in all the patients. IL-6, Procalcitonin, cardiorespiratory indices and SOFA score were compared before (T0) and at the end of the treatments (T1). Results: Of 73 patients submitted to CPFA 32 could be matched to the 22 septic patients who received RRT. 10 patients in the CPFA group experienced clotting of the adsorbing filter. Results are shown in table. Conclusions: Data from this study confirm that CPFA improves haemodynamics during septic shock. This improvement may be related to the reduction of IL-6 and of Procalcitonin. As shown in previous studies, clotting of the filter is an important problem. Anticoagulation with citrate may improve the patency of the circuit.
Published Version
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