Abstract
In the first group (n=22) there were 2 symptomatic children with unilateral hearing loss. In 4 neonates, brain imaging revealed cerebral abnormalities, but long-term clinical follow-up was normal. The second group (n=10) included abnormal cerebral findings in 5 cases. TOP was performed twice. Six children were born asymptomatically, 2 children suffered from hearing loss. In group 3 (n=4), cerebral abnormalities were present in 3 cases. There was 1 symptomatic child with bilateral hearing loss, showing periventricular signal alterations in the white tissue on prenatal MRI. In group 4 (n=6), 4 fetuses had multiple cerebral and extracerebral abnormalities. Pathological examination confirmed fetal infection in 3 cases after TOP. One neonate received antiviral treatment with normal clinical findings on follow-up. In the other remaining cases there were only solitary minor abnormalities resulting in a normal neonatal outcome. Conclusions: Most often, MRI confirms the US findings. Occasionally MRI adds important prognostic information. In case US and MRI reveal multiple infection related abnormalities, fetal outcome is poor. Both fetal imaging modalities lack sensitivity to predict hearing loss.
Published Version
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