Abstract
The development of surgery in the field of bone tissue reconstruction provides a stable demand for new materials for implants. Of particular interest are materials based on hydroxyapatite, which are close in chemical composition to the elemental composition and structure of bone and have similar biologically active properties. In this work, the regularities of the formation of new composite materials based on a zinc-modified hydroxyapatite framework coated with a copolymer of lactide and glycolide were revealed for the first time. The aim of this work was to obtain porous composite materials based on zinc-modified hydroxyapatite and a copolymer of lactide and glycolide with properties suitable for use as a material for bone implants. The phase and elemental composition of the composites was studied by infrared spectroscopy, X-ray diffraction, and X-ray spectral microanalysis. Regularities have been established between the surface properties and the composition of materials, as well as their biocompatibility, determined using monocytes isolated from human peripheral blood. The antibacterial activity of the materials against gram-positive and gram-negative bacteria was determined.
Highlights
The field of chemical materials science is actively developing, aimed at creating new multifunctional materials designed to improve the quality and life expectancy of the population
The development of new materials for bone implants requires knowledge of the chemical, physical, and mechanical properties of natural bone tissue, the qualitative and quantitative characteristics of which should be relied upon when creating implant materials
Scientists have been faced with the task of obtaining materials that are closest in their structure and functional properties to the properties of natural bone tissue
Summary
The field of chemical materials science is actively developing, aimed at creating new multifunctional materials designed to improve the quality and life expectancy of the population. Such materials are widely used, mainly in various branches of medicine. The development of new materials for bone implants requires knowledge of the chemical, physical, and mechanical properties of natural bone tissue, the qualitative and quantitative characteristics of which should be relied upon when creating implant materials. Scientists have been faced with the task of obtaining materials that are closest in their structure and functional properties to the properties of natural bone tissue. Hydroxyapatite contains impurities of Zn2+, Mg2+, Na+, CO32− etc. [3]
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